DNA/RNA Oligo Synthese
Zur Hersteller-Homepage: www.biomers.at
| Price List / Special Offers |
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| DNA-Oligonucleotides | Price List |
| RNA-Oligonucleotides | Price List |
| How to order There are several different ways to order oligonucleotides from genxpress.at : |
DNA Oligo Nucleotides
All oligonucleotides will be shipped free of salt, quantified and documented. Standard dry-cleaning with RP-cartridge;
every oligonucleotide (up to 50 bases) is assayed by Maldi mass spectrometry.
* oligonucleotides up to 35 bases, HPLC or PAGE not possible, no wobbles.
** Cartridge up to 70 bases, HPCL or PAGE up to 140 bases.
*** The lower amounts are guaranteed for a 20mer DNA oligonucleotide.
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DNA synthesis - antisense oligos |
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| Antisense drugs are designed to inhibit the production of disease-causing proteins and offer the potential to be highly selective in their action and less toxic than traditional drugs.
Antisense oligonucleotides, either as synthetic DNA or RNA, are oligonucleotides which have been modified in various ways. The purpose of this modification is to prevent oligonucleotide degradation within cells, and to increase affinity to the specific target mRNA. We deliver highly purified antisense oligos mainly as The different modifications can also be used in combination with each other to produce chimeric sequences for improved nuclease resistance and to achieve a more potent antisense activity. |
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DNA synthesis - black hole quenchers™ We can offer Black Hole (BHQ™)series of dark quenchers that were designed for use in 5’-nuclease assays. |
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| These molecules function as efficient quenchers of fluorescence over the entire visible spectrum and into the IR, re-emitting their energy as heat rather than light. Probes made with BHQ™ dyes exhibit extremely low background noise and allow for lower copy sensitivity. BHQ-1 has a maximal absorption at 534 nm, and quenches most efficiently in the 480 to 580 nm range, where as BHQ-2 has a lmax at 579 nm, which enables it to quench fluorescence in the 550 to 650 nm range.
“Black Hole Quencher™ ”, “BHQ™” are trademarks of Biosearch Technologies, Inc. BHQ™ technology is covered by patents applied for by Biosearch Technologies, Inc.
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| DNA synthesis - standard & modified special oligos With the excellent expertise of vbc´s chemists, biologists, and technicians we are able to modify oligonucleotides with a wide range of different labels as: |
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| fluorescent dyes (ABI dyes, cyanine dyes, ...) IRDyes™ (IRDye™700, IRDye™800) hapten labels (biotin, digoxigenin, DNP, ...) modified bases (Inosin, dideoxy nucleosides, methyl-dC, ...) DNA/RNA hybrids functional linkers (amine and thiol linkers in varying lengths, ...) spacers and branches (modifications for introducing spaces and branches into oligonucleotides) other modifications (phosphorylation, psoralen, cholesterol, dabcyl, ...) Together with our customers we try to find the best solution for each application. Technical support concerning optimal design and purity needs of oligonucleotides is a just as important part of our service as the synthesis of products itself. Especially new techniques developed for real-time monitoring and quantification in amplification studies, detection of RNA within living cells or big genotyping projects require the use of multiple labeled oligonucleotides. To ensure unambiguous, definite, and clear results, synthesis and purification of these specialized oligonucleotides show a strong demand for outstanding know how and highly sophisticated equipment.
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siRNA Oligonukleotide We offer RNA-Oligonucleotides for RNA-applications. si-RNA-oligos are ready to use (no further processing is required). |
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The RNA is provided with the sense and antisense strands in separate tubes. The oligos need to be duplexed by the end user. The 2´-OH protecting group has been hydrolysed to its native hydroxyl 82´-OH) form. DNA-overhangs are included in the duplex-price. |
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